During development, cells undergo dramatic changes in their morphology. These morphological changes can have a strong influence on the ability of cells to communicate, and ultimately on the differentiation patterns generated in the developing organism. Our research focuses on the effect of cell morphology on Notch signaling, which is the canonical juxtacrine signaling pathway in Metazoans, and is often involved in coordinated patterning processes such as lateral inhibition. In order to study the role of contact geometry on Notch signaling, we use both quantitative experiments and mathematical models. We combine micropatterning technology with state of the art microscopy (live confocal imaging, TIRF-FRAP, super resolution imaging) to study the dynamics of Notch receptors and ligands on the cell surface and how these dynamics affect signaling. We also develop mathematical models to understand the biophysical processes affecting Notch signaling and the effect of these processes in various developmental systems.