Selected Publications

Loza O, Heemskerk I, Gordon-Bar N, Amir-Zilberstein L, Jung Y, Sprinzak D.
A Synthetic Planar Cell Polarity System Reveals Localized Feedback on Fat4-Ds1 Complexes.  PDF
Elife. 2017 Aug 18.

Kovall RA, Gebelein B, Sprinzak D, Kopan R.
The Canonical Notch Signaling Pathway: Structural and Biochemical Insights into Shape, Sugar, and Force. PDF
Dev Cell. 2017 May 8.

Shaya O, Binshtok U, Hersch M, Rivkin D, Weinreb S, Amir-Zilberstein L, Khamaisi B, Oppenheim O, Desai RA, Goodyear RJ, Richardson GP, Chen CS, Sprinzak D.
Cell-Cell Contact Area Affects Notch Signaling and Notch-Dependent Patterning. PDF
Dev Cell. 2017 Mar 13.

Wieland E, Rodriguez-Vita J, Liebler SS, Mogler C, Moll I, Herberich SE, Espinet E, Herpel E, Menuchin A, Chang-Claude J, Hoffmeister M, Gebhardt C, Brenner H, Trumpp A, Siebel CW, Hecker M, Utikal J, Sprinzak D, Fischer A.
Endothelial Notch1 Activity Facilitates Metastasis. PDF
Cancer Cell. 2017 Mar 13.

Khait I, Orsher Y, Golan O, Binshtok U, Gordon-Bar N, Amir-Zilberstein L, Sprinzak D.
Quantitative Analysis of Delta-like 1 Membrane Dynamics Elucidates the Role of Contact Geometry on Notch Signaling. PDF
Cell Rep. 2015 Dec 30.

Bhonker Y, Abu-Rayyan A, Ushakov K, Amir-Zilberstein L, Shivatzki S, Yizhar-Barnea O, Elkan-Miller T, Tayeb-Fligelman E, Kim SM, Landau M, Kanaan M, Chen P, Matsuzaki F, Sprinzak D, Avraham KB.
The GPSM2/LGN GoLoco motifs are essential for hearing. PDF
Mamm Genome. 2015 Dec 11.

Golan T, Messer AR, Amitai-Lange A, Melamed Z, Ohana R, Bell RE, Kapitansky O, Lerman G, Greenberger S, Khaled M, Amar N, Albrengues J, Gaggioli C, Gonen P, Tabach Y,Sprinzak D, Shalom-Feuerstein R, Levy C..
Interactions of Melanoma Cells with Distal Keratinocytes Trigger Metastasis via Notch Signaling Inhibition of MITF. PDF
Mol Cell. 2015 Aug 20

Yaron T., Cordova Y., Sprinzak D.
Juxtacrine Signaling Is Inherently Noisy.
Biophys. J. (2014) vol. 107, Issue 10, Pages 2417–2424 PDF

LeBon L, Lee TV, Jafar-Nejad H, Sprinzak D, Elowitz MB.
Fringe proteins modulate Notch-ligand cis and trans interactions to specify signaling states. Elife. 2014 Sep 25;3. doi: 10.7554/eLife.02950. PDF

Jones C, Qian D, Kim SM, Li S, Ren D, Knapp L, Sprinzak D, Avraham KB, Matsuzaki F, Chi F, Chen P.
Ankrd6 is a mammalian functional homolog of Drosophila planar cell polarity gene diego and regulates coordinated cellular orientation in the mouse inner ear. Dev Biol. 2014 Sep 10. pii: S0012-1606(14)00420-5. doi: 10.1016/j.ydbio.2014.08.029. [Epub ahead of print] PDF

Formosa-Jordan P, Sprinzak D.
Modeling Notch signaling: a practical tutorial.
Methods Mol Biol. 2014;1187:285-310. doi: 10.1007/978-1-4939-1139-4_22. PDF

A. Yaron, D. Sprinzak.
The cis side of juxtacrine signaling: a new role in the development of the nervous system.
Trends Neurosci. 2012 Apr;35(4):230-9. doi: 10.1016/j.tins.2011.12.003; PDF

O. Shaya, D. Sprinzak.
From Notch signaling to fine-grained patterning: Modeling meets experiments.
Curr. Opin. Genet. Dev. 2011 Aug 19. Review PDF

D. Sprinzak, A. Lakhanpal, L. LeBon, J. Garcia-Ojalvo, M. B. Elowitz.
Mutual inactivation of Notch receptors and ligands facilitates developmental patterning
PLoS Comput. Biol. 2011 Jun;7(6) PDF

D. Sprinzak, A. Lakhanpal, L. LeBon, L. A. Santat, M. E. Fontes, G. A. Anderson, J. Garcia-Ojalvo, M. B. Elowitz.
Cis interactions between Notch and Delta generate mutually exclusive signaling states
Nature. 2010 May 6;465(729) PDF

D. Sprinzak and M. Elowitz.
Reconstruction of genetic circuits
Nature 438(7067), 443-8 (2005) Review. PDF

S. Thiberge, A. Nechushtan, D. Sprinzak, O. Gileadi, V. Behar, O. Zik, Y. Chowers, S. Michaeli, J. Schlessinger, E. Moses.
Scanning electron microscopy of cells and tissues under fully hydrated conditions
Proc. Natl. Acad. Sci. 101(10), 3346 (2004).